Nuclear Reprogramming by Human Embryonic Stem Cells
نویسندگان
چکیده
منابع مشابه
Nuclear Reprogramming by Human Embryonic Stem Cells
Embryonic stem cells have two unique properties. They are capable of indefinite self-renewal and, being pluripotent, they can differentiate into all possible cell types, including germ cells. A new study by Cowan et al. (2005) published in Science shows that human embryonic stem cells are able to reprogram the nuclei of fully differentiated human somatic cells, apparently conferring on them a p...
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The extract of pluripotent stem cells induces dedifferentiation of somatic cells with restricted plasticity. In this study, we used the extract of human embryonic stem cells (hESC) to dedifferentiate adipose tissue-derived stem cells (ADSCs) and examined the impact of this reprogramming event on dopaminergic differentiation of the cells. For this purpose, cytoplasmic extract of ESCs was prepare...
متن کاملNuclear reprogramming of somatic cells after fusion with human embryonic stem cells.
We have explored the use of embryonic stem cells as an alternative to oocytes for reprogramming human somatic nuclei. Human embryonic stem (hES) cells were fused with human fibroblasts, resulting in hybrid cells that maintain a stable tetraploid DNA content and have morphology, growth rate, and antigen expression patterns characteristic of hES cells. Differentiation of hybrid cells in vitro and...
متن کاملStem Cells and Nuclear Reprogramming
1Renova Life Inc., University of Maryland, College Park, MD 20742, USA 2Center for Regenerative Biology, University of Connecticut, Storrs, CT 06269, USA 3Consorzio di Ricerca e Sperimentazione per gli Allevatori (CRSA), 00161 Rome, Italy 4Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan 5Department of Animal Science, National Pingtung University of Sc...
متن کاملHuman Embryonic Stem Cells Derived by Somatic Cell Nuclear Transfer
Reprogramming somatic cells into pluripotent embryonic stem cells (ESCs) by somatic cell nuclear transfer (SCNT) has been envisioned as an approach for generating patient-matched nuclear transfer (NT)-ESCs for studies of disease mechanisms and for developing specific therapies. Past attempts to produce human NT-ESCs have failed secondary to early embryonic arrest of SCNT embryos. Here, we ident...
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ژورنال
عنوان ژورنال: Cell
سال: 2005
ISSN: 0092-8674
DOI: 10.1016/j.cell.2005.08.023